Uncovering the links between diet, gut health, and immunity

الكشف عن الروابط بين النظام الغذائي وصحة الأمعاء والمناعة Nature Communications (2022). DOI: 10.1038 / s41467-022-31761-y” width=”800″ top=”530″/>

A mannequin of a high-protein weight loss plan within the induction of the sIgA response. Feeding a high-protein weight loss plan enhances the manufacturing of succinate by the intestine microbiota. Excessive ranges of luminal succinate result in intestinal bacterial mobile stress and the manufacturing of reactive oxygen species (ROS), which promotes vesicle formation and will increase manufacturing of bacterial-derived extracellular vesicles. Bacterium-derived extracellular vesicles can instantly activate TLR4 expressed within the intestinal epithelium, resulting in activation of downstream NFκB signaling that results in elevated expression of APRIL, CCL28 and PIGR, leading to a T-cell-independent sIgA response. Elevated TLR4 signaling additionally potentiates pro-inflammatory responses, resulting in DSS-induced colitis. The elevated intestinal succinate noticed in IBD sufferers could contribute to the pathology of the illness by enhancing the manufacturing of microbe-derived extracellular vesicles and the TLR4/NFκB signaling pathway. attributed to him: Nature Communications (2022). DOI: 10.1038 / s41467-022-31761-y

A preclinical research from the College of Sydney discovered {that a} high-protein weight loss plan can alter the microbiome within the intestine, triggering an immune response. The researchers say the research brings us one step nearer to understanding the way in which weight loss plan impacts intestine well being and immunity.

“The main focus of our work is on how the intestine microbiota – the trillions of micro organism that dwell within the intestine – impacts the immune system,” mentioned Affiliate Professor Lawrence Macia of the Charles Perkins Heart and College Faculty of Drugs and Well being.

“Our final objective is to know how we are able to manipulate micro organism to enhance well being, and we all know that one of many best methods to alter the microbiome is to alter the weight loss plan.”

Nonetheless, scientists have historically centered on the function of dietary fiber in sustaining a wholesome intestine.

On this research, the primary of its variety, printed in Nature CommunicationsIn mice, the Charles Perkins Heart workforce used subtle modeling to discover the impact of 10 diets with completely different combos of macronutrients – protein, fats and carbohydrates.

They found {that a} high-protein weight loss plan alters the composition and exercise of the intestine microbiota.

Mice fed a high-protein weight loss plan elevated their manufacturing of extracellular bacterial vesicles, a fancy payload that comprises bacterial info corresponding to DNA and protein. The physique then considered this exercise as a menace and triggered a series of occasions as immune cells journey to the intestinal wall.

“We discovered right here that protein had a big impact on the intestine microbiota and it was not associated to the kind of micro organism there, however moderately the kind of exercise. Primarily, we found a brand new manner of communication between intestine micro organism and a protein-mediated host,” mentioned Affiliate Professor Masia.

Whereas it is too early to say whether or not this analysis would possibly translate in people, the researchers say that activating the immune system may show to be both good or dangerous information.

“By growing antibodies within the intestine, you might even see sturdy safety towards potential pathogens, for instance salmonella, however on the draw back, an lively immune system could imply you might be at elevated danger of creating colitis, inflammatory bowel illness, or autoimmune illness.” Like Crohn’s illness, lead writer and postdoctoral researcher Jian Tan mentioned.

The outcomes seem in step with the demographic impacts of contemporary diets, with the Western world experiencing decrease charges of gastrointestinal an infection however larger charges of persistent illness.

This advance in data was made attainable by incorporating the tutorial disciplines for which the Charles Perkins Heart grew to become recognized.

The research used the engineering framework for diet developed by Professor Stephen Simpson and Professor David Rubenheimer, arising from the research of ecology.

Professor Simpson mentioned: “The ‘meals engineering’ framework permits us to plan meals, meals, diets and dietary patterns collectively based mostly on their dietary composition, and this helps researchers to notice in any other case neglected patterns within the hyperlinks between sure diets and well being and illness.” , Educational Director of the Charles Perkins Heart.

“That is the primary time this mannequin has been utilized in immunology and it could solely occur right here on the Charles Perkins Centre. We’re enthusiastic about what may occur subsequent,” Affiliate Professor Masia mentioned.

Weight loss plan beats anti-aging medicine and good metabolic well being

extra info:
Jian Tan et al., Dietary protein will increase T-cell-independent sIgA manufacturing by modifications in extracellular vesicles derived from the intestine microbiota, Nature Communications (2022). DOI: 10.1038 / s41467-022-31761-y

Offered by the College of Sydney

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